The Prognostic Importance of Smoking Status at the Time of Acute Myocardial Infarction in 6676 Patients
Key result
Smoking at the time of acute myocardial infarction was not associated with reduced 30-day (RR 0.92, P=0.4) or long-term mortality (RR 0.98, P=0.7) after adjusting for age.
Why the study?
Does smoking status at the time of acute myocardial infarction independently affect 30-day and long-term mortality?
Population
6,676 consecutive patients admitted alive to hospital with an enzyme-confirmed acute myocardial infarction…
Comparison
Active smoking at the time of hospitalisation vs Non-smoking at the time of hospitalisation
Design
Cohort
Follow-up
30 days and long-term
Authors
Discussion
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Implication
Smoking at AMI admission was associated with better prognosis; leaves open whether this reflects confounding or a true effect.
Study Design
Type
Cohort (n=6,676)
Multicenter
Yes
Structured PICO
Does smoking status at the time of acute myocardial infarction independently affect 30-day and long-term mortality?
P
Population
6,676 consecutive patients admitted alive with an enzyme-confirmed acute myocardial infarction to 27 Danish hospitals, followed until October 1996.
E
Exposure
Active smoking at the time of hospitalisation
C
Comparator
Non-smoking at the time of hospitalisation
O
Outcome
30-day and long-term mortalityhard clinical
Main Result
Relative Risk: 0.92
p-value: p=0.4
The apparent survival benefit of smoking in acute myocardial infarction (the 'smoker's paradox') is entirely explained by the younger age and more favorable baseline characteristics of smokers at presentation.
Cite This Study
Jørgensen et al. (1999) conducted a cohort in Acute myocardial infarction (n=6,676). Smoking vs. Non-smokers was evaluated on 30-day mortality (age-adjusted) (RR 0.92, p=0.4). Smoking at the time of acute myocardial infarction was not associated with reduced 30-day (RR 0.92, P=0.4) or long-term mortality (RR 0.98, P=0.7) after adjusting for age.