Key result
A narrative review highlights that atrial fibrillation pathogenesis involves electrical and anatomical remodeling, impaired calcium handling, and fibrosis, which serve as emerging therapeutic targets.
Why the study?
Understanding AF pathogenesis and maintenance is a prerequisite for improving long-term success rates of evolving therapeutic options.
This narrative review highlights the complex molecular and cellular mechanisms underlying atrial fibrillation and outlines emerging therapeutic targets to combat the disease.
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Hypothesis-generating for molecular AF therapies; prospective trials needed before clinical adoption.
Papathanasiou et al. (2021) conducted a review in Atrial fibrillation. Therapeutic modalities targeting molecular perturbations was evaluated. A narrative review highlights that atrial fibrillation pathogenesis involves electrical and anatomical remodeling, impaired calcium handling, and fibrosis, which serve as emerging therapeutic targets.
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