ER stress promoted MAMs formation and ER-Mito Ca²⁺ transfer: implication for fluoride-induced hippocampal neuronal injury and cognitive deficits in mice.

Siman Lin; LuYang Cao; Yuzhe Zhou; Shengdan Liu; Yue Yan; Qiwei Zhang; Quan Yuan; Yufei Gao; Ge Du; Jun Hu; Dongmei Wang; Hua Fan

doi:10.1016/j.cbi.2026.112252

July 14, 2026

ER stress promoted MAMs formation and ER-Mito Ca²⁺ transfer: implication for fluoride-induced hippocampal neuronal injury and cognitive deficits in mice.

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Key Points

This research aims to explore the effects of ER stress on mitochondrial-associated membranes (MAMs) and calcium transfer in the context of fluoride-induced neuronal damage.
Investigated MAM formation and Ca<sup>2+</sup> transfer mechanisms using the IP3R1/Grp75/VDAC1 complex;
Evaluated cognitive deficits in mice exposed to fluoride;
Tested potential therapeutic interventions for neurotoxicity.
Fluoride exposure significantly increased ER stress and altered MAM formation;
Elevated calcium transfer correlated with neuronal injury;
Therapeutic interventions showed promise in mitigating cognitive deficits.

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Implication

Assesses calcium transfer effects on cognitive deficits in mice, indicating possible therapeutic targets.

Abstract

transfer via the IP3R1/Grp75/VDAC1 complex and provided a potential therapeutic target for the treatment of fluoride-associated neurotoxicity and neurobehavioral disorders.

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Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a59c5a7a58755010b471119 https://doi.org/10.1016/j.cbi.2026.112252

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ER stress promoted MAMs formation and ER-Mito Ca²⁺ transfer: implication for fluoride-induced hippocampal neuronal injury and cognitive deficits in mice.

Key Points

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Implication

Abstract

Discussion

Cite This Study

ER stress promoted MAMs formation and ER-Mito Ca²⁺ transfer: implication for fluoride-induced hippocampal neuronal injury and cognitive deficits in mice.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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