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July 17, 2026Cell Communication and SignalingOpen Access

TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies

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Authors

HWHaixia WangRWRuiming WenEPEmily Parker

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Overview

Review elucidates TREM2 mechanisms in neurodegenerative diseases and injuries, suggesting targeted therapies.

Key Points

  • The review aims to clarify the context-dependent roles of TREM2 in neurological conditions and injuries.
  • Synthesis of advancements in TREM2 research across various diseases.
  • Analysis of TREM2's interaction with microglia and implications of soluble TREM2.
  • Evaluation of TREM2-targeted therapies and their varied outcomes in different experimental models.
  • TREM2 influences neurodegenerative disease progression and injury outcomes in a context-dependent manner.
  • Soluble TREM2 is identified as a promising biomarker and effector in pathological regulation.
  • Divergent effects of TREM2-targeted therapies highlight the need for a tailored approach based on disease stage.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a59c6b8a58755010b471cf2https://doi.org/10.1186/s12964-026-03083-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update2026
  2. 2TREM2 in neurodegeneration and diseases2026
  3. 3TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential2025 · 14 citations
  4. 4TREM2-directed therapy in Alzheimer’s disease: from therapeutic window to clinical translation2026
  5. 5Is TREM2 a Stretch: Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease2025