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September 30, 2025CellsOpen Access

Is TREM2 a Stretch: Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease

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Authors

TPTana S. PottorfELElizabeth L. LaneFÁFrancisco J. Álvarez

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Overview

This review evaluates TREM2's involvement in neurological disease and injury, suggesting its potential therapeutic role.

Key Points

  • TREM2 plays a dual role in influencing inflammatory responses in the central nervous system and peripheral nervous system.
  • Research indicates TREM2's involvement in various neurological diseases, including neurodegenerative and autoimmune disorders.
  • The review examines TREM2's functions along spinal and peripheral nerves, highlighting its relevance to motoneurons and sensory neurons.
  • TREM2's potential as a therapeutic target could pave new paths for ameliorating damage in spinal cord sensorimotor circuits.

Cite This Study

Pottorf et al. (2025) studied this question.

synapsesocial.com/papers/68dc261d8a7d58c25ebb291ehttps://doi.org/10.3390/cells14191520
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