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September 10, 2025CellsOpen Access

TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential

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Authors

LLLing LiXZXiaoxiao ZhengHMHongyue Ma

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Overview

This review outlines TREM2's involvement in neurodegenerative diseases, emphasizing microglia's role and therapeutic implications.

Key Points

  • TREM2 serves a crucial function in regulating microglial activity and inflammation in neurodegenerative diseases.
  • Chronic neuroinflammation significantly contributes to the progression of diseases like Alzheimer’s and Parkinson’s.
  • Neurodegenerative disorders affect millions globally, highlighting the urgent need for targeted therapies.
  • Understanding TREM2 pathways may inform potential therapeutic strategies against neurodegenerative diseases.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1924e9b7b07f3a0616ab7https://doi.org/10.3390/cells14171387
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TREM2 in neurodegeneration and diseases2026 · 10 citations
  2. 2TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies2026
  3. 3Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update2026
  4. 4Is TREM2 a Stretch: Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease2025 · 1 citations
  5. 5Is TREM2 a Stretch? Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease2025