Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 25, 2025Open Access

Is TREM2 a Stretch? Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

TPTana S. PottorfELElizabeth L. LaneFÁFrancisco J. Álvarez

Discussion

Loading...

Member takes

Overview

Review shows TREM2 influences inflammatory responses in CNS and PNS, highlighting its potential as a therapeutic target.

Key Points

  • TREM2 plays a critical role in modulating inflammatory responses, which can affect motor functions and health outcomes.
  • Involvement of TREM2 in various neurological diseases suggests it could be a promising therapeutic avenue.
  • The review discusses TREM2's functions across spinal cord circuits and peripheral nerves, emphasizing its dual role in health and injury.
  • Understanding TREM2's mechanisms may lead to breakthroughs in treating conditions related to spinal and sensory circuit damage.

Cite This Study

Pottorf et al. (2025) studied this question.

synapsesocial.com/papers/68af63efad7bf08b1eae4bedhttps://doi.org/10.20944/preprints202508.1769.v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Is TREM2 a Stretch: Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease2025 · 1 citations
  2. 2TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies2026
  3. 3TREM2 in neurodegeneration and diseases2026 · 10 citations
  4. 4Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update2026
  5. 5TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential2025 · 14 citations