Key result
Cardioneuroablation resolves recurrent syncope and enables return to endurance training in an athlete.
Why the study?
Cardioneuroablation is an emerging therapy for cardioinhibitory vasovagal syncope, but its autonomic effects in athletes remain poorly defined.
Does cardioneuroablation resolve cardioinhibitory vasovagal syncope and allow return to sport in an endurance athlete?
Case Report (n=1)
No
Does cardioneuroablation resolve cardioinhibitory vasovagal syncope and allow return to sport in an endurance athlete?
Cardioneuroablation is a viable, pacemaker-sparing treatment for cardioinhibitory vasovagal syncope in athletes, though it may cause transient reflex orthostatic tachycardia requiring temporary medical management.
Answers are grounded in this paper and cite their sources.
May offer pacemaker alternative in select athletes with cardioinhibitory syncope; leaves open need for prospective trials.
BACKGROUND: Cardioneuroablation (CNA) is an emerging therapy for cardioinhibitory vasovagal syncope, but its autonomic effects in athletes remain poorly defined. CASE SUMMARY: A 44-year-old endurance athlete presented with recurrent syncope and a documented 20-second sinus pause. Structural heart disease was excluded, and tilt testing was nondiagnostic. To avoid pacemaker implantation and preserve athletic capacity, targeted CNA of the paraseptal ganglionated plexi was performed. This resulted in increased resting heart rate and a blunted atropine response. Shortly after, she developed symptomatic orthostatic tachycardia with hypotension. Symptoms resolved with short-term, low-dose beta-blocker therapy, which was subsequently discontinued. At a 12-month follow-up, she remained asymptomatic and returned to unrestricted endurance training. DISCUSSION: Although CNA is increasingly used to treat vasovagal syncope, postprocedural autonomic imbalance, including reflex tachycardia, is under-recognized, particularly in athletes. TAKE-HOME MESSAGES: CNA may induce transient orthostatic tachycardia in athletes. Anticipatory counseling and structured follow-up are essential.
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Beiser et al. (2026) conducted a case report in Cardioinhibitory vasovagal syncope (n=1). Cardioneuroablation was evaluated on Symptom resolution and return to athletic activity at 12 months. Cardioneuroablation prevented recurrent syncope and allowed return to unrestricted endurance training in a 44-year-old athlete, despite inducing transient orthostatic tachycardia.
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