Key result
Initial CT pattern correlates with clinical severity in amiodarone-induced pulmonary toxicity.
Case Report (n=6)
The radiographic pattern on CT scan in patients with amiodarone-induced pulmonary toxicity correlates with clinical severity and can guide management.
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May aid prognosis in amiodarone pulmonary toxicity; hypothesis-generating and requires prospective validation before practice change.
Amiodarone is an effective and commonly used anti-arrhythmic drug. The radiographic presentations of amiodarone-induced pulmonary toxicity (AIPT) include a broad spectrum of patterns. Three main clinical-radiographic presentations are described with AIPT: isolated reduction of diffusing lung capacity with no clinical implications; alveolar-interstitial pneumonia, which usually requires amiodarone discontinuation and corticosteroid treatment; and acute respiratory distress syndrome, which can obviously be life-threatening. We report 6 cases that depict the described range of clinical and radiographic presentations. The analysis of the cases and of the published review suggests that the computed tomography scan pattern on presentation predicts well the clinical course. The correlation between radiographic and clinical findings can therefore guide the clinician in the management of AIPT.
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Zagà et al. (2026) conducted a case report in Amiodarone-induced pulmonary toxicity (n=6). Amiodarone was evaluated. The computed tomography scan pattern on presentation of amiodarone-induced pulmonary toxicity correlates with and predicts the severity of the clinical course.
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