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May 3, 2019Regional blood circulation and microcirculationOpen Access

Diagnosis and dynamic control of vascular disorders in patients with amiodarone-induced pulmonary toxicity (AIPT)

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Why the study?

To estimate radiologic features and follow up vascular disorders in the lungs among patients with amiodarone-induced pulmonary toxicity.

Population

110 patients with history of amiodarone use (90 confirmed AILT cases)

Follow-up

From 1 month up to 10 years

Authors

NYN. S. YakovlevaASA. A. SperanskaiaVZV. P. Zolotnitskaia

Discussion

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Overview

CT patterns in AILT are nonspecific and mimic other diseases; leaves open subtype-specific management and prospective validation needs.

Structured PICO

P
Population
110 patients with a history of amiodarone use, including 90 cases with confirmed amiodarone-induced pulmonary toxicity (AIPT). Among confirmed cases: mean age 71 years, 21 females, 69 males.
I
Intervention
Radiological evaluation including CT exams, lung scintigraphy (SPECT-CT), functional lung tests, and cardiac ultrasound
O
Outcome
Radiologic features and dynamic control of vascular disorders in the lungssurrogate

Amiodarone-induced pulmonary toxicity leads to persistent, irreversible lung changes and microcirculation disorders, with SPECT being highly informative for evaluating perfusion.

Cite This Study

Yakovleva et al. (2019) studied this question.

synapsesocial.com/papers/6a90d83ffae915895c3607a4https://doi.org/10.24884/1682-6655-2019-18-1-66-76
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical features of amiodarone-induced pulmonary toxicity.1990 · 243 citations
  2. 2Amiodarone pulmonary toxicity. Clinical, radiologic, and pathologic correlations1987 · 117 citations
  3. 3The Role of Free Radicals in the Pathogenesis of Amiodarone Toxicity1993 · 71 citations
  4. 4Induction of c-junand TGF-β1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis2001 · 26 citations
  5. 5Practical Guidelines for Clinicians Who Treat Patients With Amiodarone2000 · 225 citations