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January 1, 2014The Korean Journal of Internal MedicineOpen Access

Patients with positive amiodarone-induced pulmonary toxicity CT scores exhibited significantly lower diffusion capacity for carbon monoxide compared to those with negative scores (70.2% vs. 89.7%, p=0.011).

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Why the study?

Does chest computed tomography (CT) scoring predict the severity of amiodarone-induced pulmonary toxicity in patients receiving long-term amiodarone therapy?

Population

34 patients who underwent amiodarone treatment for more than 2 years with a cumulative dose > 100 g, most…

Comparison

Chest computed tomography scoring vs Patients without an increased APT CT score

Design

Cohort

Key result

Patients with positive amiodarone-induced pulmonary toxicity CT scores exhibited significantly lower diffusion capacity for carbon monoxide compared to those with negative scores (70.2% vs. 89.7%, p=0.011).

Authors

IKIn Sook KangKKKyung Jin KimYKYookyung Kim

Discussion

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Member takes

Overview

Supports CT scoring for amiodarone pulmonary toxicity severity assessment; hypothesis-generating and requires prospective validation.

Study Design

Type

Cohort (n=34)

Multicenter

No

Structured PICO

Does chest computed tomography (CT) scoring predict the severity of amiodarone-induced pulmonary toxicity in patients receiving long-term amiodarone therapy?

P
Population
34 patients treated with amiodarone for over 2 years with a cumulative dose >100 g, evaluated with chest CT and followed for 1 year to assess pulmonary toxicity.
E
Exposure
Chest computed tomography (CT) scoring (APT CT score)
C
Comparator
Patients without an increased APT CT score
O
Outcome
Feasibility of chest CT as a diagnostic tool for amiodarone-induced pulmonary toxicity (APT) and utility of the CT APT score as an index for predicting the severity of APTsurrogate

Main Result

Absolute Event Rate: 70.2% vs 89.7%

p-value: p=0.011

Chest CT scoring is a feasible and useful diagnostic index for assessing the severity of amiodarone-induced pulmonary toxicity in patients on long-term therapy.

Limitations

  • Small subject number
  • Single-center study
  • Baseline PFT data were not available
  • Chest CTs were not repeated routinely during follow-up

Cite This Study

Kang et al. (2014) conducted a cohort in Amiodarone-induced pulmonary toxicity (n=34). Positive APT CT score vs. Negative APT CT score was evaluated on Diffusion capacity for carbon monoxide (DLCO) (p=0.011). Patients with positive amiodarone-induced pulmonary toxicity CT scores exhibited significantly lower diffusion capacity for carbon monoxide compared to those with negative scores (70.2% vs. 89.7%, p=0.011).

synapsesocial.com/papers/6a5d777eeea3ca2688880596https://doi.org/10.3904/kjim.2014.29.6.746
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Computed Tomography in the Diagnosis of Various Forms of Amiodarone-Induced Pulmonary Toxicity2019
  2. 2Diagnosis of Amiodarone Pulmonary Toxicity with HighResolution Computerized Tomographic Scan2001 · 45 citations
  3. 3Amiodarone pulmonary toxicity: CT findings in symptomatic patients.1990 · 123 citations
  4. 4Amiodarone-Induced Pulmonary Toxicity – A Frequently Missed Complication2016 · 23 citations
  5. 5Diagnosis and dynamic control of vascular disorders in patients with amiodarone-induced pulmonary toxicity (AIPT)2019