Amiodarone-induced pulmonary toxicity can present with an unusual, symmetric appearance on CT and should be considered in the differential diagnosis of pulmonary parenchymal infiltrates in patients receiving this medication.
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Atypical symmetric CT infiltrates may signal amiodarone toxicity; leaves open broader diagnostic utility pending larger series.
Amiodarone, an antiarrhythmic agent, is known to induce pulmonary toxicity in some patients. Previously described radiographic findings include alveolar and interstitial infiltrates. We report a patient who developed biapical infiltrates on chest X-ray film and demonstrated an unusual, symmetric appearance on CT. Correlative postmortem histologic findings are presented. Amiodarone-induced pulmonary toxicity should be considered in the differential diagnosis of pulmonary parenchymal infiltrates seen on CT of patients receiving this medication.
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Butler et al. (1985) studied this question.
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