Key result
TAVR increases net blood flow in the ascending aorta and brachiocephalic artery in low-flow aortic stenosis.
Why the study?
Although TAVR can improve cerebral blood flow in patients with AS, the effect of pre-TAVR flow rate on post-TAVR flow rate increase is unclear.
Does TAVR improve blood flow in the ascending aorta and brachiocephalic artery in patients with aortic stenosis?
Cohort (n=61)
Does TAVR improve blood flow in the ascending aorta and brachiocephalic artery in patients with aortic stenosis?
p-value: p=0.23 for AAo, 0.06 for BCA
TAVR significantly increases ascending aorta and brachiocephalic artery blood flow specifically in patients with low-flow aortic stenosis.
BACKGROUND: Although transcatheter aortic valve replacement (TAVR) can improve cerebral blood flow (CBF) in patients with aortic stenosis (AS), the effect of pre-TAVR flow rate on post-TAVR flow rate increase is unclear. We aimed to evaluate blood flow changes before and after TAVR in the ascending aorta (AAo) and brachiocephalic artery (BCA) using four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) and assess whether the post-TAVR flow response depends on the pre-TAVR flow rate. METHODS: for the ratio of pre-TAVR AAo flow rate per beat to body surface area. Flow rates in the AAo and BCA were analyzed. RESULTS: Sixty-one patients were enrolled. The median age was 84 (82-87) years, and twenty-three patients (38%) were men. The net flow rates in the AAo and BCA increased after TAVR, but the changes were not statistically significant (AAo, 3206 (2499-3975) mL/min vs. 3591 (2880-4419) mL/min, p = 0.23; BCA, 435 (302-560) mL/min vs. 512 (377-666) mL/min, p = 0.06). In the analysis of the NF and LF groups, the LF group demonstrated significant increases in net flow after TAVR (AAo, 2598 (1972-3079) vs. 3468 (2900-4131) mL/min, p < 0.001; BCA, 365 (230-529) vs. 522 (377-659) mL/min, p = 0.006). CONCLUSION: 4D flow CMR revealed that TAVR significantly increased the AAo and BCA flow rates in patients with LF AS. (274 words / 350 limit).
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Yamasaki et al. (2026) conducted a cohort in Aortic stenosis (n=61). Transcatheter aortic valve replacement (TAVR) vs. Pre-TAVR baseline was evaluated on Net flow rates in the ascending aorta (AAo) and brachiocephalic artery (BCA) (p=0.23 for AAo, 0.06 for BCA). Transcatheter aortic valve replacement significantly increased net blood flow in the ascending aorta (p<0.001) and brachiocephalic artery (p=0.006) in patients with low-flow aortic stenosis.
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