Key result
Continuous veno-venous hemodiafiltration successfully cleared dabigatran in a 9 g overdose, achieving a mean clearance of 58.1 and 31.9 ml/h and a mean extraction ratio of 0.2.
Why the study?
Does continuous veno-venous hemodiafiltration effectively clear dabigatran in a hemodynamically unstable patient with massive overdose?
Population
A 66-year-old male presenting with a poly-pharmacy overdose including 9 g of dabigatran, complicated by…
Design
Case_report
Follow-up
32 hours
Authors
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May support CVVHDF for dabigatran clearance in overdose; hypothesis-generating and requires prospective validation.
Case Report (n=1)
Does continuous veno-venous hemodiafiltration effectively clear dabigatran in a hemodynamically unstable patient with massive overdose?
Continuous veno-venous hemodiafiltration can effectively clear dabigatran and facilitate full recovery in hemodynamically unstable patients following massive overdose.
Chiew et al. (2014) conducted a case report in Dabigatran overdose (n=1). Continuous veno-venous hemodiafiltration was evaluated on Clearance of dabigatran. Continuous veno-venous hemodiafiltration successfully cleared dabigatran in a 9 g overdose, achieving a mean clearance of 58.1 and 31.9 ml/h and a mean extraction ratio of 0.2.
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