Key result
Underweight adults with HIV on long-term antiretroviral therapy had a 27% lower carotid-femoral augmentation index compared to normal-weight individuals, indicating less arterial stiffness.
Why the study?
The prevalence and characteristics of impaired vascular compliance among persons with HIV and low BMI are not well described, particularly in sub-Saharan Africa where low BMI is more common and CVD burden is rising.
Does BMI category affect vascular compliance measurements in persons with HIV on long-term antiretroviral therapy?
Cross-Sectional (n=91)
No
Does BMI category affect vascular compliance measurements in persons with HIV on long-term antiretroviral therapy?
In persons with HIV on long-term ART, low BMI is associated with lower carotid-femoral augmentation index but similar pulse wave velocity compared to normal weight, suggesting low BMI may not substantially protect against impaired vascular compliance.
BACKGROUND: Impaired vascular compliance is common among persons with HIV (PWH) and a risk factor for cardiovascular disease (CVD), though many studies documenting this are from regions with a high prevalence of overweight and obesity. The prevalence and characteristics of impaired vascular compliance among PWH with low body mass index (BMI) is not well described, particularly in sub-Saharan Africa (SSA) where the majority of PWH live, a low BMI is more common, and the burden of CVD is rising. AIM: To assess non-invasive vascular compliance measurements, including augmentation index (AIX), pulse wave velocity (PWV) and pulse waveforms, in underweight, normal weight, and overweight PWH on long-term antiretroviral therapy (ART) in SSA. METHODS: A cross-sectional study among PWH on ART at the University Teaching Hospital in Lusaka, Zambia. All participants had been on a regimen of efavirenz, emtricitabine, and tenofovir disoproxil fumarate for five or more years. Carotid-femoral PWV (cfPWV), carotid-radial PWV (crPWV), and the corresponding augmentation indexes (cfAIX and crAIX), were measured in all participants, in addition to aortic pressure waveforms, classified as type A, B, C and D according to reflected wave timings and amplitude. Multiple linear regression assessed relationships between demographic and clinical factors with vascular measurement endpoints. Median age was 41, 40 and 40 years, among the three groups, respectively, and the proportion of women increased with BMI level. Overweight participants had a 39% higher cfAIX compared to normal-weight participants, while being underweight was associated with 27% lower cfAIX, after adjusting for age, sex and blood pressure (P = 0.02 and P = 0.01, respectively), but measurements of cfPWV, crPWV and crAIX did not differ. CONCLUSION: Underweight PWH in SSA had lower cfAIX measurements compared to normal weight individuals, indicating less arterial stiffness. However, similar cfPWV, crPWV and crAIX values among the underweight and overweight PWH suggest a low BMI may not confer substantial protection against impaired vascular compliance as a contributor to CVD risk among individuals on ART.
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Kaluba et al. (2023) conducted a cross-sectional in HIV (n=91). Underweight (BMI < 18.5 kg/m2) vs. Normal weight (BMI 18.5-24.9 kg/m2) was evaluated on Carotid-femoral augmentation index (cfAIX) (MD -27.0, 95% CI -44.7 to -9.27, p=0.01). Underweight adults with HIV on long-term antiretroviral therapy had a 27% lower carotid-femoral augmentation index compared to normal-weight individuals, indicating less arterial stiffness.
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