Key result
Bariatric surgery halted the natural progression of carotid intima-media thickness over a 10-year observation period compared to a significant increase in a matched population-based control cohort.
Why the study?
Previous studies showed short-to-mid-term arrest of C-IMT progression after bariatric surgery, but the long-term effect on C-IMT progression 10 years post-surgery compared to a control cohort remained uninvestigated.
Does bariatric surgery prevent carotid intima media thickness progression in patients with severe obesity?
Cohort (n=42)
Does bariatric surgery prevent carotid intima media thickness progression in patients with severe obesity?
Absolute Event Rate: 0% vs 0.18%
p-value: p=<0.01
Bariatric surgery halts the natural progression of subclinical atherosclerosis, as measured by carotid intima media thickness, over a 10-year period in patients with severe obesity.
May attenuate carotid atherosclerosis progression; leaves open cardiovascular event reduction in randomized trials.
BACKGROUND: Bariatric surgery is a treatment option for patients with severe obesity and improves parameters of cardiovascular and/or metabolic disease. Carotid intima media thickness (C-IMT) is a surrogate measure of subclinical atherosclerosis. Previous studies showed short to mid-term arrest and even regression of C‑IMT progression following bariatric surgery. We aimed to investigate the long-term effect of weight loss on C‑IMT progression 10 years after bariatric surgery in comparison to a population-based control cohort. METHODS: In total, 21 eligible patients were examined preoperatively, at 5 and 10 years after bariatric surgery. Anthropometric parameters, plasma triglycerides, total cholesterol, high-density lipoprotein cholesterol (HDL-C), insulin, and glucose were assessed at all three study visits. C‑IMT was measured via B‑mode scans of the common carotid artery. C‑IMT progression was measured in an age-matched and BMI-matched cohort selected from the population-based Bruneck study to compare with changes in C‑IMT progression after bariatric surgery. RESULTS: C‑IMT remained stable over the 10-year observation period after bariatric surgery. The control cohort showed a significant C‑IMT progression over 10 years. The difference in C‑IMT progression over 10 years was significant (p < 0.01) between both cohorts. CONCLUSION: Weight loss induced by bariatric surgery halts the natural progression of C‑IMT over a 10-year observation period.
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Lunger et al. (2022) conducted a cohort in Severe obesity (n=42). Bariatric surgery vs. Population-based control cohort was evaluated on Carotid intima-media thickness (C-IMT) progression over 10 years (p=<0.01). Bariatric surgery halted the natural progression of carotid intima-media thickness over a 10-year observation period compared to a significant increase in a matched population-based control cohort.
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