Key result
This review outlines the genetics, diagnostic criteria, pathophysiology, and clinical management of hypertrophic cardiomyopathy, noting that differing mechanisms prevent a unified therapeutic approach.
This review discusses the genetics, diagnosis, pathophysiology, and management of hypertrophic cardiomyopathy, including the prevention of sudden cardiac death.
Differing HCM mechanisms preclude unified therapy; leaves open mechanism-specific trials.
Hypertrophic cardiomyopathy is a rare primary myocardial disease known for its dramatic morphologic and clinical manifestations. Sudden cardiac death and functional cardiac symptoms are common. However, differing pathologic mechanisms may be responsible for similar clinical symptoms and make a unified approach to therapy impossible. This review will discuss the genetics, criteria for diagnosis, relationship among pathophysiologic abnormalities and clinical symptoms, and management of hypertrophic cardiomyopathy.
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Dohlen et al. (1990) conducted a review in Hypertrophic cardiomyopathy. This review outlines the genetics, diagnostic criteria, pathophysiology, and clinical management of hypertrophic cardiomyopathy, noting that differing mechanisms prevent a unified therapeutic approach.
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