Key result
Excessive cardiac insulin signaling exacerbated systolic dysfunction induced by pressure overload in rodents by increasing myocardial hypoxia and cardiomyocyte death.
Why the study?
Does excessive cardiac insulin signaling exacerbate systolic dysfunction induced by pressure overload in rodents?
Does excessive cardiac insulin signaling exacerbate systolic dysfunction induced by pressure overload in rodents?
Excessive cardiac insulin signaling exacerbates pressure overload-induced heart failure, suggesting that using insulin to control hyperglycemia in this setting could be harmful.
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May caution insulin use in pressure overload; hypothesis-generating for human systolic HF.
Shimizu et al. (2010) studied Heart failure induced by pressure overload. Excessive cardiac insulin signaling was evaluated on Systolic dysfunction. Excessive cardiac insulin signaling exacerbated systolic dysfunction induced by pressure overload in rodents by increasing myocardial hypoxia and cardiomyocyte death.
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