Key result
Time-average values of wall shear stress are sufficient to locate regions of higher LDL concentration, and this correlation is unaffected by blood rheology or wall curvature.
Why the study?
Understanding arterial diseases like stenosis and aneurysms is linked to hemodynamic parameters such as wall shear stress, motivating generalization of its influence on LDL concentration.
Time-averaged wall shear stress is sufficient to identify regions of high LDL concentration in arterial models, independent of blood rheology and wall curvature.
Supports simplified LDL modeling in vascular research; leaves open human translation from animal data.
Differences in the dynamics and transport of blood make certain regions of the arterial network the preferred sites for initiation and formation of arterial diseases like stenosis and aneurysms. Understanding of such arterial diseases is directly linked to critical hemodynamic parameters such as the wall shear stress (WSS). The present work generalises the influence of WSS on the concentration of LDL that was observed in an earlier study. To this end, a wide variety of simplified flow domain, inspired by the near-wall regions of aneurysms and stenosis, are constructed and analyzed. The effects of pulsatile inflow condition, rheology of blood and curvature of the wall on the correlation between WSS and LDL concentration are investigated. It is demonstrated that the time-scale of variation of lumen-surface-concentration (LSC) of LDL is larger than a single cardiac cycle. As a consequence, the time-average values of WSS are sufficient to locate the regions of higher LSC. This idea is strengthened by making use of simplified flow domain that generates moving stagnation point. Further, it was observed that the rheology of the blood and curvature of the wall does not affect the observed correlation between the WSS and LDL concentration.
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Choudhury et al. (2021) studied Arterial diseases (stenosis and aneurysms). Wall shear stress (WSS) was evaluated on Correlation between WSS and LDL concentration. Time-average values of wall shear stress are sufficient to locate regions of higher LDL concentration, and this correlation is unaffected by blood rheology or wall curvature.
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