Key result
In a computational model, simulating an ischemic stroke with a clot in the right middle cerebral artery reduced RMCA flow by 88.4% and overall inlet flow by 21.5%.
Why the study?
Prediction of perfusion rates and hemodynamics in the circle of Willis is necessary to understand relevant vascular diseases and prescribe effective treatments.
Computational modeling demonstrates that an RMCA clot significantly reduces local and overall inlet flow rates in the circle of Willis despite compensatory increases in other inlets.
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These modeled RMCA flow reductions remain hypothesis-generating; leaves open validation in clinical stroke populations.
Darvish et al. (2021) studied Ischemic stroke and anatomical variations of the circle of Willis (n=1). Simulated ischemic stroke (spherical clot in the right middle cerebral artery) vs. Complete and healthy circle of Willis was evaluated on Flow rates in the circle of Willis branches. In a computational model, simulating an ischemic stroke with a clot in the right middle cerebral artery reduced RMCA flow by 88.4% and overall inlet flow by 21.5%.
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