Key result
PCA vasoconstriction predominantly decreases vertebral flow, while ACA and MCA vasoconstriction reduces internal carotid flow.
Why the study?
The effects of physiological and pathological changes in the peripheral small cerebral vasculature on flow through the Circle of Willis were not well understood.
Changes in inflow arteries (vertebral and internal carotid) may serve as monitorable indicators of peripheral small cerebral vasculature vasoconstriction associated with diseased states like Alzheimer's.
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May enable inflow monitoring of cerebral vasoconstriction in disease; leaves open human validation for Alzheimer's.
Šutalo et al. (2014) studied Cerebral hemodynamics. Computational Fluid Dynamics (CFD) and 1D branching tree model vs. Geometric variations with communicating arteries missing was evaluated on Flow rate variation in the Circle of Willis. Vasoconstriction of the posterior cerebral artery peripheral vasculature predominantly decreases vertebral artery flow, while anterior and middle cerebral artery vasoconstriction decreases internal carotid flow.
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