Key result
High stromal POSTN expression in the cancer microenvironment is correlated with poor prognosis and higher cisplatin resistance in epithelial ovarian cancer patients.
Observational
High stromal periostin expression in epithelial ovarian cancer is associated with poor prognosis and platinum resistance, potentially mediated through the AKT pathway.
Stromal POSTN should not yet guide ovarian cancer management; leaves open its value as a biomarker or target in prospective trials.
// Pi-Lin Sung 1, 2 , Yi-Hua Jan 3 , Shih-Chieh Lin 4 , Chao-Cheng Huang 5 , Hao Lin 6 , Kuo-Chang Wen 1, 2 , Kuan-Chong Chao 2 , Chiung-Ru Lai 4 , Peng-Hui Wang 2 , Chi-Mu Chuang 2 , Hua-Hsi Wu 2 , Nae-Fang Twu 2 , Ming-Shyen Yen 2 , Michael Hsiao 3 , Chi-Ying F. Huang 1, 7 1 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan 2 Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan and School of Medicine, National Yang-Ming University, Taipei, Taiwan 3 Genomics Research Center, Academia Sinica, Taipei, Taiwan 4 Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan 5 Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 6 Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 7 Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan Correspondence to: Michael Hsiao, e-mail: mhsiao@gate.sinica.edu.tw Chi-Ying F. Huang, e-mail: cyhuang5@ym.edu.tw Keywords: periostin, platinum resistance, biomarker, microenvironment, epithelial ovarian cancer Received: May 14, 2015 Accepted: December 02, 2015 Published: December 21, 2015 ABSTRACT The interplay between tumor microenvironment and cancer that causes chemoresistance remains unclear. By analyzing public available microarray datasets, we identified that periostin (POSTN) was overexpressed in cancer stroma in epithelial ovarian cancer (EOC) patients. Immunohistochemistry analysis showed overexpression of stromal POSTN is a powerful independent poor prognostic predictor for EOC patients. Furthermore, patients with high levels of stromal POSTN tend to have higher percentage of cisplatin resistance compared to those with low levels of stromal POSTN. Moreover, we found POSTN treatment can induce cisplatin resistant and activate AKT pathway in A2780 cells in vitro . Inhibition of AKT activity by AKT inhibitor MK-2206 abolished POSTN-induced AKT activation and cisplatin resistance in vitro . Taken together, we found high POSTN expression in cancer microenvironment is correlated with poor prognosis in EOC patients and associated with platinum resistance. The effect of POSTN in cancer stroma cells may activate AKT pathway in tumor and AKT inhibitor can be beneficial to augment the efficacy of existing cancer therapeutics.
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Sung et al. (2015) conducted an observational in Epithelial ovarian cancer. High stromal POSTN expression vs. Low stromal POSTN expression was evaluated on Prognosis and cisplatin resistance. High stromal POSTN expression in the cancer microenvironment is correlated with poor prognosis and higher cisplatin resistance in epithelial ovarian cancer patients.
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