What question did this study set out to answer?

The study aims to identify factors associated with cause-specific death in breast cancer patients receiving extended adjuvant endocrine therapy.

February 12, 2008JNCI Journal of the National Cancer InstituteOpen Access

Competing Causes of Death From a Randomized Trial of Extended Adjuvant Endocrine Therapy for Breast Cancer

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The study aims to identify factors associated with cause-specific death in breast cancer patients receiving extended adjuvant endocrine therapy.
Randomized trial with 5170 breast cancer patients assigned to letrozole or placebo after 5 years of tamoxifen
Median follow-up of 3.9 years, assessing baseline factors' associations with competing death risks
Statistical analysis using two-sided likelihood ratio tests for associations with different causes of death
256 total deaths reported: 102 from breast cancer, 50 from other malignancies, 100 from other causes
Non-breast cancer deaths occurred in 60% of known deaths, with 72% in women aged 70 and over
Cardiovascular disease significantly increased risk for other causes (P=0.002), and osteoporosis increased risk for other malignancies (P=0.05)

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Implication

Randomized trial examines death causes in women after extended adjuvant endocrine therapy for breast cancer, indicating significant non-cancer mortality.

Cite This Study

Chapman et al. (2008) studied this question.

synapsesocial.com/papers/6a5ba1ef1121af0b87129bb6 https://doi.org/10.1093/jnci/djn014

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Implication

Randomized trial examines death causes in women after extended adjuvant endocrine therapy for breast cancer, indicating significant non-cancer mortality.

Competing Causes of Death From a Randomized Trial of Extended Adjuvant Endocrine Therapy for Breast Cancer

Key Points

Discussion

Implication

Cite This Study

Competing Causes of Death From a Randomized Trial of Extended Adjuvant Endocrine Therapy for Breast Cancer

Key Points

Discussion

Implication

Cite This Study

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