Key result
Endothelin-1 promotes tumorigenesis by modulating mitogenesis, apoptosis, angiogenesis, and metastasis, highlighting endothelin receptor antagonism as a potential adjuvant therapeutic strategy.
Endothelin-1 plays a multifaceted role in tumorigenesis and may serve as a target for adjuvant therapeutic strategies in cancer.
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Endothelin receptor antagonism should not yet change cancer practice; leaves open its adjuvant potential pending prospective trials.
Grant et al. (2003) conducted a review in Cancer. Endothelin-1 was evaluated. Endothelin-1 promotes tumorigenesis by modulating mitogenesis, apoptosis, angiogenesis, and metastasis, highlighting endothelin receptor antagonism as a potential adjuvant therapeutic strategy.
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