Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts

Figures

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  Figure 1.. (A) Depression trajectories in ALSPAC split by IL-6 tertile groups. (B) Differences in depression scores in ALSPAC between the top and bottom third IL-6 tertiles. Results from the fully adjusted model. Mean depressive scores were calculated from the depression trajectories in each IL-6 tertile at ages 10, 13, 16, 19, 22, 25, and 28 years. Differences between the top and bottom third IL-6 tertile trajectories were calculated using the delta method. P-values are corrected for multiple corrections (FDR).

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  Figure 2.. (A) Depression trajectories in ALSPAC split by sex and IL-6 tertile groups. (B) Differences in depression scores in ALSPAC between the top and bottom third IL-6 tertiles, in males and females, separately. Results from the fully adjusted model. Mean depressive scores were calculated from the depression trajectories in each IL-6 tertile split by sex at ages 10, 13, 16, 19, 22, 25, and 28 years. Differences between the top and bottom third IL-6 tertile trajectories were calculated using the delta method. P-values are corrected for multiple corrections (FDR).

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  Figure 3.. (A) Depression trajectories in UK Biobank split by IL-6 tertile groups. (B) Differences in depression scores in UK Biobank between the top and bottom third IL-6 tertiles. Results from the fully adjusted model. Mean depressive scores were calculated from the depression trajectories in each IL-6 tertile at ages 40, 50, 60, 70, and 80 years. Differences between the top and bottom third IL-6 tertile trajectories were calculated using the delta method. P-values are corrected for multiple corrections (FDR).

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  Figure 4.. (A) Depression trajectories in UK Biobank split by sex and IL-6 tertile groups. (B) Differences in depression scores in UK Biobank between the top and bottom third IL-6 tertiles, in males and females separately. Results from the fully adjusted model. Mean depressive scores were calculated from the depression trajectories in each IL-6 tertile split by sex at ages 40, 50, 60, 70, and 80 years. Differences between the top and bottom third IL-6 tertile trajectories were calculated using the delta method. P-values are corrected for multiple corrections (FDR).