Key result
Higher baseline levels of the inflammatory biomarker IL-6 were significantly associated with the persistence of depressive symptoms over 5 years (OR 2.44) in older adults.
Why the study?
Do higher baseline levels of inflammatory biomarkers predict the persistence of depressive symptoms over 5 years in older adults?
Cohort (n=656)
No
Do higher baseline levels of inflammatory biomarkers predict the persistence of depressive symptoms over 5 years in older adults?
Odds Ratio: 2.44 (95% CI 1.09–5.45)
p-value: p=0.030
Elevated baseline levels of IL-6 and CRP predict the persistence of depressive symptoms over 5 years in older adults, suggesting a role for low-grade inflammation in chronic depression.
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May flag older adults for persistent depression risk; hypothesis-generating for inflammation-targeted trials.
Zalli et al. (2015) conducted a cohort in Depressive symptoms (n=656). Elevated inflammatory biomarkers (IL-6) vs. Lower levels of inflammatory biomarkers was evaluated on Persistence of depressive symptoms over 5 years (CES-D score ≥16 at baseline and follow-up) (OR 2.44, 95% CI 1.09-5.45, p=0.030). Higher baseline levels of the inflammatory biomarker IL-6 were significantly associated with the persistence of depressive symptoms over 5 years (OR 2.44) in older adults.
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