Key result
High levels of blood inflammatory proteins did not significantly predict the risk of developing incident depression in older age after adjustment for confounders.
Why the study?
Do high levels of blood inflammatory proteins predict the risk of developing depression in late life?
Cohort (n=968)
Do high levels of blood inflammatory proteins predict the risk of developing depression in late life?
Blood inflammatory proteins do not appear to independently predict the risk of developing depression in older age.
Does not support inflammatory marker use for late-life depression prediction; leaves open independent causality in adjusted observational models.
BACKGROUND: It is unclear whether high levels of blood inflammatory proteins are associated with the risk of developing depression in late life. METHODS: Blood C-reactive protein, interleukin (IL)-6, 1 -antichymotrypsin (ACT), intercellular adhesion molecule 1, and tumor necrosis factor were measured in an elderly cohort (n = 968). Major depression diagnosed according to clinical criteria and relevant depressive symptoms measured by the Geriatric Depression Scale (score 6 10) were assessed at baseline and 4 year later. RESULTS: Baseline IL-6 and ACT were increased in both prevalent major depression and relevant depressive symptoms. Baseline ACT was increased in incident major depression. All associations weakened below significance after adjustment for possible confounders and multiple comparisons. CONCLUSIONS: Blood inflammatory proteins do not predict the risk of developing depression in older age.
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Forti et al. (2010) conducted a cohort in Depression (n=968). High levels of blood inflammatory proteins (CRP, IL-6, ACT, ICAM-1, TNF) was evaluated on Incident major depression and relevant depressive symptoms. High levels of blood inflammatory proteins did not significantly predict the risk of developing incident depression in older age after adjustment for confounders.
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