January 1, 2003Epidemiology
Inflammatory Proteins and Depression in the Elderly
Key result
Increased levels of interleukin-6 were associated with depressive disorders in older adults (OR per standard deviation increase 1.47; 95% CI 1.15-1.89).
Why the study?
Are elevated levels of inflammatory proteins associated with depression in elderly adults?
Population
3,884 adults at age 60 and older living in a district of Rotterdam. The analysis compared 263 cases with…
Design
Case-control
Authors
Discussion
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Implication
IL-6 elevation may flag depressive risk in older adults; leaves open causality and need for prospective trials.
Study Design
Type
Case-Control (n=724)
Multicenter
No
Structured PICO
Are elevated levels of inflammatory proteins associated with depression in elderly adults?
P
Population
724 adults aged 60 and older, including 263 cases with depressive symptoms and 461 reference subjects, drawn from a population-based screening in Rotterdam.
O
Outcome
Association of inflammatory markers (interleukin-6, alpha1-antichymotrypsin, and C-reactive protein) with depressive symptoms and depressive disorders
Main Result
Odds Ratio: 1.47 (95% CI 1.15–1.89)
Elevated interleukin-6 levels are independently associated with depressive disorders in the elderly, suggesting a potential specific immunologic process, whereas associations with acute phase proteins are likely due to confounding.
Cite This Study
Tiemeier et al. (2003) conducted a case-control in Depression (n=724). Interleukin-6 vs. Reference subjects was evaluated on Depressive disorders (OR 1.47, 95% CI 1.15-1.89). Increased levels of interleukin-6 were associated with depressive disorders in older adults (OR per standard deviation increase 1.47; 95% CI 1.15-1.89).