Key result
Atypical depressive symptoms were associated with elevated hsCRP levels compared to non-depressed individuals (OR 2.59; 95% CI 1.40-4.81), as were non-atypical symptoms (OR 1.42; 95% CI 1.05-1.92).
Why the study?
The association between systemic inflammation and depressive symptoms has been less convincing at the population level among individuals without a formal depression diagnosis.
Are atypical and non-atypical depressive symptoms associated with elevated hsCRP levels in a middle-aged general population cohort?
Cross-Sectional (n=5,443)
Are atypical and non-atypical depressive symptoms associated with elevated hsCRP levels in a middle-aged general population cohort?
Odds Ratio: 2.59 (95% CI 1.4–4.81)
Both atypical and non-atypical depressive symptoms are associated with elevated systemic inflammation (hsCRP) in the general population, with a stronger association seen in the atypical subtype.
Depressive symptoms linked to higher hsCRP in general population; supports prior inflammation associations but leaves causal direction open.
Purpose Individuals with depression exhibit significantly higher levels of systemic inflammation than those without depression, particularly among those with atypical depression. However, this association has been less convincing at the population level among individuals without a formal depression diagnosis but with suggestive symptoms. Our aim was to clarify this association.Materials and methods In a large birth cohort sample of the Finnish general population, we examined the cross-sectional association between high-sensitivity C-reactive protein (hsCRP) levels in venous blood samples and atypical/non-atypical depressive symptoms using the Beck Depression Inventory-II to screen 5443 middle-aged participants.Results As expected, depressive symptoms associated to elevated hsCRP-levels compared to non-depressed. Participants with the atypical subtype of depressive symptoms (n = 84) had an odds ratio (OR) of 2.59 (95% CI 1.40–4.81) for elevated hsCRP levels compared to the non-depressed group. Similarly, our findings indicate that participants with non-atypical symptoms (n = 440) also showed an OR of 1.42 (95% CI 1.05–1.92) when compared to the non-depressed group (n = 4919).Conclusions These results provide additional support for previous research linking depression and inflammation and add to the field with a unique and sizeable study population. Furthermore, the current results support the notion that different types of depressive symptoms may be associated with inflammatory markers in slightly different ways.
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Moilanen et al. (2023) conducted a cross-sectional in Depressive symptoms (n=5,443). Atypical depressive symptoms vs. Non-depressed group was evaluated on Elevated hsCRP levels (OR 2.59, 95% CI 1.40-4.81). Atypical depressive symptoms were associated with elevated hsCRP levels compared to non-depressed individuals (OR 2.59; 95% CI 1.40-4.81), as were non-atypical symptoms (OR 1.42; 95% CI 1.05-1.92).
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