March 18, 2009Psychosomatic Medicine
Depression and C-Reactive Protein: Population-Based Health 2000 Study
Key result
Higher depression scores were associated with elevated C-reactive protein levels in men (beta = 0.12, p<0.001) and women (beta = 0.08, p<0.001), though it only persisted after adjustment in men.
Why the study?
Is depression independently associated with elevated levels of C-reactive protein in a population-based sample?
Population
6005 Finns aged >30 years from the population-based Health 2000 Study
Comparison
Depression vs Lower depression scores or absence of depression
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Should not change practice; extends cross-sectional evidence on sex-specific links but remains hypothesis-generating.
Study Design
Type
Cross-Sectional (n=6,005)
Multicenter
Yes
Structured PICO
Is depression independently associated with elevated levels of C-reactive protein in a population-based sample?
P
Population
6,005 Finnish adults aged >30 years from a nationwide population-based sample assessed for the association between depression and C-reactive protein levels.
E
Exposure
Depression (assessed by Beck's Depression Inventory [BDI-21] and Composite International Diagnostic Interview [CIDI])
C
Comparator
Lower depression scores or absence of depression
O
Outcome
C-reactive protein (CRP) levelssurrogate
Main Result
Effect estimate: beta = 0.12 (men), beta = 0.08 (women)
p-value: p=<0.001
Depression is independently associated with elevated CRP levels in men, suggesting a sex-specific link between depressive symptoms and systemic inflammation.
Cite This Study
Elovainio et al. (2009) conducted a cross-sectional in Depression (n=6,005). Depression vs. Lower depression scores or absence of depression was evaluated on Elevated levels of C-reactive protein (CRP) (beta = 0.12 (men), beta = 0.08 (women), p=<0.001). Higher depression scores were associated with elevated C-reactive protein levels in men (beta = 0.12, p<0.001) and women (beta = 0.08, p<0.001), though it only persisted after adjustment in men.