Key result
High CRP concentration (>3 mg/l) was not significantly associated with depression in older men after adjusting for physical co-morbidity and other confounding factors (OR 1.22; 95% CI 0.86-1.73).
Why the study?
Is high CRP concentration associated with depression in older men independent of physical health?
Cross-Sectional (n=5,438)
Is high CRP concentration associated with depression in older men independent of physical health?
Odds Ratio: 1.22 (95% CI 0.86–1.73)
p-value: p=non-significant
The association between elevated CRP and depression in older men is likely driven by underlying physical co-morbidity rather than a direct physiological role of CRP in depression.
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Does not support CRP as an independent marker for depression in older men; leaves open inflammation's direct role after comorbidity adjustment.
Almeida et al. (2007) conducted a cross-sectional in depression (n=5,438). High C-reactive protein (CRP) concentration (> 3 mg/l) vs. CRP ≤ 3 mg/l was evaluated on clinically significant depressive symptoms (GDS-15 score ≥ 7) (OR 1.22, 95% CI 0.86-1.73, p=non-significant). High CRP concentration (>3 mg/l) was not significantly associated with depression in older men after adjusting for physical co-morbidity and other confounding factors (OR 1.22; 95% CI 0.86-1.73).
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