Key result
High midlife CRP in CHD is linked to ~136% higher risk of depressive symptoms decades later.
Why the study?
The authors investigated the relationship between midlife C-reactive protein levels in men with coronary heart disease and depressive symptoms at old age.
Does high midlife C-reactive protein increase the risk of depressive symptoms two decades later in men with coronary heart disease?
Cohort (n=463)
Does high midlife C-reactive protein increase the risk of depressive symptoms two decades later in men with coronary heart disease?
Odds Ratio: 2.36 (95% CI 1.16–4.83)
p-value: p=0.018
Midlife low-grade inflammation in men with coronary heart disease is associated with an increased risk of developing depressive symptoms two decades later.
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May link midlife CRP to later depression in CHD survivors; leaves open causality and clinical relevance.
Ravona‐Springer et al. (2019) conducted a cohort in Coronary heart disease (n=463). High C-reactive protein (CRP) levels (top tertile) vs. Lower CRP levels (other tertiles) was evaluated on Potentially clinically significant depressive symptoms (GDS ≥5) at 19.9 ± 1 years (OR 2.36, 95% CI 1.16-4.83, p=0.018). High midlife C-reactive protein levels in men with coronary heart disease were associated with an increased risk of depressive symptoms two decades later (OR 2.36; 95% CI 1.16-4.83; P=0.018).
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