Key result
Among men aged 17 to 39, a history of major depressive episode was associated with significantly higher odds of elevated CRP compared with never-depressed men (OR 2.77; 95% CI 1.43-5.26).
Why the study?
Is a history of major depressive episode associated with elevated CRP levels in young adults free of cardiovascular disease?
Cross-Sectional (n=6,149)
Yes
Is a history of major depressive episode associated with elevated CRP levels in young adults free of cardiovascular disease?
Odds Ratio: 2.77 (95% CI 1.43–5.26)
A recent history of major depression is strongly associated with elevated CRP in young men, suggesting low-grade systemic inflammation may be a mechanism linking depression to cardiovascular risk.
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May link depression to early CVD risk via inflammation in young men; hypothesis-generating and requires longitudinal confirmation before practice implications.
Danner et al. (2003) conducted a cross-sectional in Depression (n=6,149). History of major depressive episode vs. Never-depressed individuals was evaluated on Presence of an elevated CRP level (> or =22 mg/dl) (OR 2.77, 95% CI 1.43-5.26). Among men aged 17 to 39, a history of major depressive episode was associated with significantly higher odds of elevated CRP compared with never-depressed men (OR 2.77; 95% CI 1.43-5.26).
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