Key result
Graded lower body negative pressure in older men and cardiac patients resulted in lesser tachycardia and stroke index decline, but greater increases in peripheral resistance compared to younger men.
Why the study?
Does age and coronary heart disease alter the circulatory responses to graded lower body negative pressure?
Population
Healthy men aged 20 to 27 years, healthy men aged 50 to 59 years, and ambulatory coronary heart disease…
Comparison
Graded lower body negative pressure (LBNP) vs Comparison between the three groups
Design
Cross-sectional
Authors
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Altered LBNP responses in older and CHD patients warrant caution during autonomic testing; leaves open standardization for clinical risk assessment.
Observational
Does age and coronary heart disease alter the circulatory responses to graded lower body negative pressure?
Decreased haemodynamic responses to postural stress in older subjects and cardiac patients are partly due to lesser peripheral blood sequestration, with diminished preload stress responses primarily attributable to normal aging.
Ebert et al. (1982) conducted an observational in Coronary heart disease. Graded lower body negative pressure (LBNP) vs. Younger healthy men (20-27 years) was evaluated on Changes in stroke index, thoracic blood volume, and vascular resistance. Graded lower body negative pressure in older men and cardiac patients resulted in lesser tachycardia and stroke index decline, but greater increases in peripheral resistance compared to younger men.
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