Key result
Older healthy men demonstrated lower leg compliance and higher orthostatic tolerance during lower body negative pressure compared to younger men, alongside attenuated baroreflex sensitivity.
Why the study?
Does aging affect cardiovascular response and baroreflex sensitivity during lower body negative pressure in healthy individuals?
Population
37 healthy male subjects, comprising 15 old subjects and 22 young subjects
Comparison
21-min bout of ramped lower body negative… vs Young male subjects (for age comparison)
Design
Cross-sectional
Follow-up
21 minutes
Authors
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Healthy elderly men maintain orthostatic tolerance similar to young; leaves open effects of comorbidities on baroreflex responses.
Observational (n=37)
Does aging affect cardiovascular response and baroreflex sensitivity during lower body negative pressure in healthy individuals?
Aging does not increase intolerance to orthostatic stress induced by LBNP, partly due to lower leg compliance reducing the magnitude of venous return reduction.
Tsutsui et al. (2002) conducted an observational in Healthy (n=37). Older age vs. Younger age was evaluated on Cardiovascular response and baroreflex sensitivity during lower body negative pressure. Older healthy men demonstrated lower leg compliance and higher orthostatic tolerance during lower body negative pressure compared to younger men, alongside attenuated baroreflex sensitivity.
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