Key result
Male sex is linked to ~2.7-fold higher odds of the CLOCK rs11932595 variant in MI.
Why the study?
Cardiovascular disease incidence and circadian rhythm vary by biological sex, but potential sex differences in circadian rhythm gene polymorphisms in myocardial infarction require examination.
Does the distribution of circadian clock gene polymorphisms differ between women and men with myocardial infarction?
Cross-Sectional (n=200)
No
Does the distribution of circadian clock gene polymorphisms differ between women and men with myocardial infarction?
Genetic variability in the CLOCK gene differs significantly between women and men with myocardial infarction, suggesting a sex-specific role for circadian genes in cardiovascular disease susceptibility.
Answers are grounded in this paper and cite their sources.
Observed sex difference in CLOCK rs11932595 genotype prevalence among MI patients should not change practice; leaves open sex-specific circadian gene roles in MI susceptibility.
The growing body of evidence shows a significant difference in the circadian rhythm of cardiovascular disease based on biological sex. The incidence of cardiovascular disease varies between women and men. Additionally, biological sex is vital for the timely application of therapy—chronotherapy, which benefits both sexes. This study aimed to examine the potential difference of single nucleotide polymorphisms (SNPs) of the circadian rhythm genes ARNTL, CLOCK, CRY2 and PER2 in women and men with myocardial infarction. A cross-sectional study was conducted, including 200 patients with myocardial infarction. Altogether, ten single nucleotide polymorphisms in the ARNTL, CLOCK, CRY2 and PER2 genes were analyzed. The Chi-square test yielded statistically significant differences in CLOCK gene rs11932595 polymorphism in a recessive genotype model between women and men with a p-value of 0.03 and an odds ratio 2.66, and a corresponding 95% confidence interval of 1.07 to 6.66. Other analyzed polymorphisms of the circadian rhythm genes ARNTL, CRY2, and PER2 did not significantly differ between the sexes. According to the study’s current results, the CLOCK gene’s genetic variability might affect myocardial infarction concerning biological sex.
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Škrlec et al. (2021) conducted a cross-sectional in Myocardial Infarction (n=200). Female sex vs. Male sex was evaluated on CLOCK gene rs11932595 polymorphism (recessive genotype model) (OR 2.66, 95% CI 1.07-6.66, p=0.03). Female sex was associated with a significantly lower prevalence of the CLOCK gene rs11932595 recessive genotype compared to men among patients with myocardial infarction (OR 2.66).
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