Key result
AA-induced LTA and VerifyNow reliably detected aspirin intake (100% sensitivity), whereas ADP-induced LTA, TEG, and urinary 11-dHTB2 assays showed wide pre- and post-aspirin overlap.
Why the study?
Does the choice of platelet function assay affect the detection of aspirin-mediated effects in healthy individuals?
Population
45 non-smoking healthy volunteers, 19-59 years old, not taking any drug known to interfere with platelet…
Comparison
Aspirin 80 mg daily for 8-10 days vs Baseline (pre-aspirin intake)
Design
Cohort
Follow-up
8-10 days
Authors
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May inform clinicians' assay selection for aspirin adherence checks; leaves open standardization across populations.
Does the choice of platelet function assay affect the detection of aspirin-mediated effects in healthy individuals?
Variability in reported 'aspirin resistance' may be largely driven by the inherent limitations of certain platelet function assays rather than true biological non-response.
Pharand et al. (2009) studied Healthy individuals (n=45). Aspirin vs. Baseline (pre-aspirin) was evaluated on Sensitivity, specificity, and optimal cut-off value to detect the effect of aspirin across five assays. AA-induced LTA and VerifyNow reliably detected aspirin intake (100% sensitivity), whereas ADP-induced LTA, TEG, and urinary 11-dHTB2 assays showed wide pre- and post-aspirin overlap.
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