Key result
Current smoking was associated with a 15-fold increased risk of abdominal aortic aneurysm in women (RR 15.0; 95% CI 13.2-17.0) and a 7-fold increased risk in men (RR 7.3; 95% CI 6.4-8.2).
Why the study?
Large studies are needed for reliable estimates of important risk factors for AAA to guide targeted screening programs, particularly in subgroups like women who are currently excluded.
Population
1.5 million women and 0.8 million men without known vascular disease
Comparison
Vascular risk factors related to AAA across sexes
Design
Cross-sectional study
Authors
Loading...
May inform targeted AAA screening criteria in women; leaves open prospective validation for outcomes.
Cross-Sectional (n=2,300,000)
Yes
Relative Risk: 15 (95% CI 13.2–17)
Female smokers have a substantially higher risk of developing an abdominal aortic aneurysm than male never-smokers, challenging current screening policies that exclude women.
Carter et al. (2020) conducted a cross-sectional in abdominal aortic aneurysm (n=2,300,000). Current smoking vs. Never smoking was evaluated on abdominal aortic aneurysm (RR 15.0, 95% CI 13.2-17.0). Current smoking was associated with a 15-fold increased risk of abdominal aortic aneurysm in women (RR 15.0; 95% CI 13.2-17.0) and a 7-fold increased risk in men (RR 7.3; 95% CI 6.4-8.2).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: