June 22, 2016British journal of surgery
Risk factors associated with increased prevalence of abdominal aortic aneurysm in women
Key result
A multivariable model including age ≥76 years, stroke/TIA, hypertension, smoking, ABPI, atrial fibrillation, and carotid stenosis identified women with an AAA prevalence of 1.57% (AUC 0.775).
Why the study?
Can high-risk groups of women be identified with an abdominal aortic aneurysm prevalence of 1% or greater to justify targeted screening?
Population
50,000 women who attended private cardiovascular screening in the UK
Design
Cross-sectional
Authors
Discussion
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Implication
May support targeted AAA screening in high-risk women; hypothesis-generating and requires prospective validation.
Study Design
Type
Cross-Sectional (n=50,000)
Structured PICO
Can high-risk groups of women be identified with an abdominal aortic aneurysm prevalence of 1% or greater to justify targeted screening?
P
Population
50,000 women attending private cardiovascular screening in the UK evaluated for AAA prevalence and associated risk factors.
O
Outcome
Prevalence of abdominal aortic aneurysm (AAA) 3.0 cm or larger
Main Result
Effect estimate: AUC 0.775 (95% CI 0.724-0.826)
Targeted screening for abdominal aortic aneurysm in women over 65 with specific cardiovascular risk factors can identify a subpopulation with a prevalence >1%, potentially making screening economically viable.
Cite This Study
Chabok et al. (2016) conducted a cross-sectional in Abdominal aortic aneurysm (n=50,000). Cardiovascular risk factors (age, stroke/TIA, hypertension, smoking, ABPI, atrial fibrillation, carotid stenosis) was evaluated on Prevalence of AAA ≥3.0 cm (AUC 0.775, 95% CI 0.724-0.826). A multivariable model including age ≥76 years, stroke/TIA, hypertension, smoking, ABPI, atrial fibrillation, and carotid stenosis identified women with an AAA prevalence of 1.57% (AUC 0.775).