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This research investigates the role of GDF15 as a potential treatment for obesity by analyzing its effects on metabolism and body weight.

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

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Randomized trial evaluates GDF15's effect on body weight and metabolism in mice and monkeys, suggesting therapeutic potential.

This research investigates the role of GDF15 as a potential treatment for obesity by analyzing its effects on metabolism and body weight.
Microarray study comparing gene expression in metabolic tissues of ob/ob and C57BL/6 mice.
Adeno-associated virus-mediated overexpression of GDF15 and recombinant GDF15 treatments.
Analysis of GDF15's crystal structure to design Fc fusion molecules with extended half-life.
GDF15 treatment reduced food intake and body weight in mice and obese cynomolgus monkeys.
GDF15 was found to delay gastric emptying and influence food preference.
Fc fusion proteins demonstrated potent efficacy for metabolic profile improvement.

Xiong et al. (2017) studied this question.

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