What question did this study set out to answer?

To determine whether physiological levels of the circulating cytokine MIC-1/GDF15 regulate appetite, body weight, and basal metabolic rate.

February 28, 2013SHILAP Revista de lepidopterologíaOpen Access

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

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Authors

VTVicky Wang-Wei TsaiSt Vincent's Hospital LMLaurence MaciaThe University of Sydney HJHeiko JohnenConsejo Superior de Investigaciones Científicas

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Implication

Animal study demonstrates that circulating MIC-1/GDF15 regulates food intake and adiposity in mice, indicating a physiological role in energy homeostasis.

Key Points

To determine whether physiological levels of the circulating cytokine MIC-1/GDF15 regulate appetite, body weight, and basal metabolic rate.
Generated and phenotyped MIC-1/GDF15 gene knockout mice (MIC-1(-/-)) to assess body weight, adiposity, food intake, energy expenditure, and activity.
Administered human recombinant MIC-1/GDF15 infusions into MIC-1(-/-) mice to restore serum concentrations to normal human physiological levels.
MIC-1(-/-) mice exhibited significantly increased body weight and adiposity driven by elevated spontaneous food intake.
Female MIC-1(-/-) mice displayed reductions in basal energy expenditure and spontaneous physical activity alongside decreased total lean mass.
Infusion of human recombinant MIC-1/GDF15 restored circulating levels within the normal physiological range and reduced both food intake and body weight.

Cite This Study

Tsai et al. (2013) studied this question.

synapsesocial.com/papers/69da291e84371aa676a3ce8e https://doi.org/10.1371/journal.pone.0055174

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Implication

Animal study demonstrates that circulating MIC-1/GDF15 regulates food intake and adiposity in mice, indicating a physiological role in energy homeostasis.

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

Discussion

Member takes

Implication

Key Points

Cite This Study

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

Discussion

Member takes

Implication

Key Points

Cite This Study

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