Key result
Specific components of the smooth muscle cell glycocalyx mediate the mechanotransduction of shear stress into a contractile response, which is unaffected by the rate of shear stress application.
Population
Rat aortic smooth muscle cells (SMCs)
Comparison
Exposure to a step increase or a ramp increase… vs Untreated cells and comparison between step…
Design
Preclinical
Authors
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Hypothesis-generating for vascular mechanotransduction; leaves open shear-rate effects on human aortic SMC function.
Specific components of the vascular smooth muscle cell glycocalyx, specifically heparan sulfate and chondroitin sulfate, are essential for the mechanotransduction of shear stress into a contractile response.
Ainslie et al. (2004) studied this question. Shear stress application (step vs ramp) and glycosaminoglycan removal was evaluated on Cell contraction (cell area reduction). Specific components of the smooth muscle cell glycocalyx mediate the mechanotransduction of shear stress into a contractile response, which is unaffected by the rate of shear stress application.
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