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January 1, 1991Cell Structure and FunctionOpen Access

Flow Effects on Cultured Vascular Endothelial and Smooth Muscle Cell Functions.

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Population

Cultured vascular endothelial cells and smooth muscle cells

Comparison

Fluid shear stress by means of a rotary-disc… vs Static cells

Design

Preclinical

Authors

OOOhmi OnoHokkaido UniversityJAJoji AndoDokkyo UniversityAKAkira KamiyaHokkaido University of Science

Discussion

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Implication

Shear-loaded endothelium may drive vascular remodeling; hypothesis-generating for atherosclerosis mechanisms and should not yet change practice.

Structured PICO

P
Population
Cultured vascular endothelial cells and smooth muscle cells
I
Intervention
Fluid shear stress by means of a rotary-disc shear-loading device
C
Comparator
Static cells
O
Outcome
Effects of conditioned medium and homogenate on migration, adhesion and growth of endothelial cells or smooth muscle cells, and production and secretion of collagensurrogate

Fluid shear stress induces endothelial cells to produce stimulators of smooth muscle cell migration and enhances collagen production.

Cite This Study

Ono et al. (1991) studied this question.

synapsesocial.com/papers/6a707f5bfebe604dd7094766https://doi.org/10.1247/csf.16.365
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Dynamic Response of Vascular Endothelial Cells to Fluid Shear Stress1981 · 1,144 citations
  2. 2Adaptive regulation of wall shear stress to flow change in the canine carotid artery1980 · 827 citations
  3. 3Substratum-bound elastin peptide inhibits aortic smooth muscle cell migration in vitro.1987 · 80 citations
  4. 4Polarity of arachidonic acid metabolism by bovine aortic endothelial cell monolayers1987 · 15 citations
  5. 5A disk-type apparatus for applying fluid shear stress on cultured endothelial cell1988 · 28 citations