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Migraine is a chronic disease that affects 12 percent of the general population. In addition to severe, debilitating headache, patients with migraines may experience nausea, vomiting, and sensitivity to light and sound. Migraine remains one of the most underdiagnosed and undertreated neurologic conditions and has substantial socioeconomic effects in developed countries. It is now considered to be a neurovascular disorder because its pathology involves important interactions between the cerebral nerves and blood vessels.Current theories propose that migraine-specific triggers promote primary brain dysfunction, which evokes changes in the dilation of meningeal blood vessels and the activation of perivascular trigeminal nerves. . . .
Paul L. Durham (Wed,) studied this question.