Among 400 subjects, prediabetes was associated with early signs of subclinical disease, including increased risk for carotid plaque, adverse cardiac parameters, and elevated fat levels.
Case-Control (n=400)
Does prediabetes increase the burden of subclinical vascular, cardiac, and metabolic disease assessed by whole-body MRI compared to healthy controls?
Prediabetes is associated with early subclinical vascular, cardiac, and metabolic changes detectable by whole-body MRI, highlighting the systemic impact of early dysglycemia prior to overt cardiovascular disease.
Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, coronary artery disease, or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MRI assessment to characterize cerebral parameters (white matter lesions, microbleeds), cardiovascular parameters (carotid plaque, left ventricular function, and myocardial late gadolinium enhancement LGE), and metabolic parameters (hepatic proton-density fat fraction PDFF and subcutaneous and visceral abdominal fat). Among 400 subjects who underwent MRI, 103 subjects had prediabetes and 54 had established diabetes. Subjects with prediabetes had an increased risk for carotid plaque and adverse functional cardiac parameters, including reduced early diastolic filling rates as well as a higher prevalence of LGE compared with healthy control subjects. In addition, people with prediabetes had significantly elevated levels of PDFF and total and visceral fat. Thus, subjects with prediabetes show early signs of subclinical disease that include vascular, cardiac, and metabolic changes, as measured by whole-body MRI after adjusting for cardiometabolic risk factors.
Bamberg et al. (Mon,) conducted a case-control in Prediabetes (n=400). Prediabetes vs. Healthy control subjects was evaluated on Subclinical disease burden (cerebral, cardiovascular, and metabolic parameters assessed by whole-body MRI). Among 400 subjects, prediabetes was associated with early signs of subclinical disease, including increased risk for carotid plaque, adverse cardiac parameters, and elevated fat levels.