Key result
Knockout mice develop cellular compensatory mechanisms and possess cardiovascular systems significantly different from humans, complicating the extrapolation of experimental results.
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Design
Editorial
Highlights the limitations and potential pitfalls of extrapolating cardiovascular research findings from mouse models to humans.
Most scientists are becoming aware that KO mice often develop cellular compensatory mechanisms that can 'muddy' the predicted results. This problem is often compounded because many physiologists and molecular biologists do not understand how different even the mouse and rat cardiovascular systems are, let alone mouse versus man.
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Hamlin et al. (2011) studied this question. Knockout mice develop cellular compensatory mechanisms and possess cardiovascular systems significantly different from humans, complicating the extrapolation of experimental results.
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