Key result
Muscle-derived myokines, including irisin, myonectin, and FGF21, play crucial roles in inter-organ crosstalk and represent promising novel therapeutic targets and biomarkers for diabetic nephropathy.
Why the study?
With the increasing incidence of diabetic nephropathy, effective preventive and therapeutic modalities are urgently needed, but the beneficial role of exercise and underlying molecular mechanisms have rarely been reported.
Do myokines serve as effective therapeutic targets for diabetic nephropathy?
Do myokines serve as effective therapeutic targets for diabetic nephropathy?
Myokines represent a potential novel therapeutic target for the prevention and treatment of diabetic nephropathy.
Myokine pathways may mediate exercise benefits in DN; leaves open targeted trials before clinical adoption.
With the increasing incidence of diabetic nephropathy (DN), there is an urgent need to find effective DN preventive and therapeutic modalities. It is widely believed that effective exercise is good for health. However, the beneficial role of exercise in kidney disease, especially in DN, and the underlying molecular mechanisms have rarely been reported. Muscle is not only an important motor organ but also an important endocrine organ, secreting a group of proteins called "myokines" into the blood circulation. Circulating myokines then move to various target organs to play different biological roles. In this review, we summarize the currently known myokines and the progress in research relating them to DN and discuss its potential as a therapeutic target for DN.
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Yang et al. (2022) conducted a review in Diabetic nephropathy. Myokines (e.g., Irisin, FGF21, Myonectin) was evaluated. Muscle-derived myokines, including irisin, myonectin, and FGF21, play crucial roles in inter-organ crosstalk and represent promising novel therapeutic targets and biomarkers for diabetic nephropathy.
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