Key result
Intravenous dexamethasone significantly increased maximum postoperative blood glucose compared with ondansetron in both non-diabetic (9.1 vs 7.8 mmol/L) and diabetic patients (14.0 vs 10.7 mmol/L).
Why the study?
Does intravenous dexamethasone increase postoperative blood glucose levels compared to ondansetron in non-diabetic and diabetic patients?
RCT (n=85)
Randomly allocated
Does intravenous dexamethasone increase postoperative blood glucose levels compared to ondansetron in non-diabetic and diabetic patients?
p-value: p=<0.01
Dexamethasone given for postoperative nausea and vomiting prophylaxis significantly increases postoperative blood glucose levels in both non-diabetic and diabetic patients compared to ondansetron.
May support perioperative glucose monitoring with dexamethasone; leaves open confirmation in larger randomized trials.
There are few data regarding postoperative hyperglycaemia in non-diabetic compared with diabetic patients following postoperative nausea and vomiting prophylaxis with dexamethasone. Eighty-five non-diabetic patients and patients with type-2 diabetes were randomly allocated to receive intravenous dexamethasone (8 mg) or ondansetron (4 mg). Blood glucose levels were measured at baseline and then 2, 4 and 24 h following induction of anaesthesia. In non-diabetic patients, the mean (SD) maximum blood glucose was higher in those who received dexamethasone compared with ondansetron (9.1 (2.2) mmol.l(-1) vs. 7.8 (1.4) mmol.l(-1) , p = 0.04). In diabetic patients, the mean (SD) maximum blood glucose was also higher in those who received dexamethasone compared with ondansetron (14.0 (2.5) mmol.l(-1) vs. 10.7 (2.4) mmol.l(-1) , p < 0.01). Multivariate analysis demonstrated that dexamethasone administration was a significant predictor of maximum postoperative blood glucose increase (p < 0.01) after adjusting for potential confounders. There was no interaction between baseline blood glucose level, or presence or absence of diabetes, and dexamethasone administration. We conclude that dexamethasone increases postoperative blood glucose levels in both non-diabetics and diabetics.
No takes yet. Share an insight, caveat, or question.
Tien et al. (2016) conducted an RCT in Postoperative nausea and vomiting (n=85). Dexamethasone vs. Ondansetron (4 mg) was evaluated on Maximum postoperative blood glucose level (p=<0.01). Intravenous dexamethasone significantly increased maximum postoperative blood glucose compared with ondansetron in both non-diabetic (9.1 vs 7.8 mmol/L) and diabetic patients (14.0 vs 10.7 mmol/L).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: