Key result
A single 8 mg oral dose of dexamethasone before abdominal hysterectomy caused a more pronounced increase in blood glucose compared to placebo (elevated glucose in 61% vs 24%; interaction P=0.02).
Why the study?
Does a single oral dose of 8 mg dexamethasone increase blood glucose in non-diabetic women undergoing abdominal hysterectomy?
RCT (n=90)
randomised
Does a single oral dose of 8 mg dexamethasone increase blood glucose in non-diabetic women undergoing abdominal hysterectomy?
Absolute Event Rate: 61% vs 24%
p-value: p=0.02
A single 8 mg oral dose of dexamethasone used for postoperative nausea and vomiting prophylaxis causes short-lasting hyperglycemia in non-diabetic women undergoing abdominal hysterectomy.
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Clinicians should monitor glucose after dexamethasone PONV prophylaxis; RCT extends hyperglycemic risk data to oral dosing in non-diabetic women.
Eberhart et al. (2010) conducted an RCT in abdominal hysterectomy (n=90). dexamethasone vs. placebo was evaluated on elevated glucose concentrations (>7 mmol l⁻¹) (p=0.02). A single 8 mg oral dose of dexamethasone before abdominal hysterectomy caused a more pronounced increase in blood glucose compared to placebo (elevated glucose in 61% vs 24%; interaction P=0.02).
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