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Demonstrates the creation of functionalized sulfonyl fluoride pharamacophores, suggesting innovative pathways in drug design.
A chemoselective [4 + 2] annulation protocol employing 2-aminostyrylsulfonyl fluoride and isothiocyanates was established, enabling selective access to two distinct classes of 3,1-benzothiazine- and tetrahydroquinazoline-functionalized sulfonyl fluorides. This method provides a novel approach for constructing highly functionalized sulfonyl fluoride pharmacophores that hold significant potential in the fields of medicinal chemistry, chemical biology, and drug discovery.
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Xin-ke et al. (2026) studied this question.
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